IER3

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.^[5][6]

AliasesIER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3

External IDsOMIM: 602996; MGI: 104814; HomoloGene: 2894; GeneCards: IER3; OMA:IER3 - orthologs

Chr.Chromosome 6 (human)^[1]

End30,744,548 bp^[1]

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IER3
Identifiers
Aliases	IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3
External IDs	OMIM: 602996; MGI: 104814; HomoloGene: 2894; GeneCards: IER3; OMA:IER3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,743,199 bp[1] End 30,744,548 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 36,132,576 bp[2] End 36,133,815 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa islet of Langerhans gastric mucosa gallbladder body of stomach granulocyte bone marrow left uterine tube vagina right auricle of heart Top expressed in right lung lobe granulocyte decidua stroma of bone marrow cervix motor neuron endothelial cell of lymphatic vessel left lung corneal stroma superior surface of tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane membrane nucleus cytosol Biological process anatomical structure morphogenesis regulation of response to DNA damage stimulus negative regulation of apoptotic process apoptotic process regulation of phosphatidylinositol 3-kinase signaling regulation of cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8870 15937 Ensembl ENSG00000137331 ENSMUSG00000003541 UniProt P46695 P46694 Q91VZ5 RefSeq (mRNA) NM_052815 NM_003897 NM_133662 RefSeq (protein) NP_003888 NP_598423 Location (UCSC) Chr 6: 30.74 – 30.74 Mb Chr 17: 36.13 – 36.13 Mb PubMed search [3] [4]
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This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.^[7]