IFITM3

IFITM3
Identifiers
Aliases	IFITM3, 1-8U, DSPA2b, IP15, interferon induced transmembrane protein 3
External IDs	OMIM: 605579; MGI: 1913391; HomoloGene: 136199; GeneCards: IFITM3; OMA:IFITM3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	329,475 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,590,683 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; Descending thoracic aorta; ; left coronary artery; ; pericardium; ; ascending aorta; ; upper lobe of left lung; ; right coronary artery; ; canal of the cervix; ; right lung; ; body of uterus;
	Top expressed in
	aortic valve; ; right lung lobe; ; carotid body; ; granulocyte; ; uterus; ; ascending aorta; ; cervix; ; left lobe of liver; ; calvaria; ; ankle joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; endosome; membrane; late endosome membrane; plasma membrane; lysosomal membrane; lysosome; protein-containing complex;
Biological process	negative regulation of viral entry into host cell; response to interferon-gamma; immune system process; response to virus; response to interferon-beta; response to biotic stimulus; negative regulation of viral genome replication; type I interferon signaling pathway; immune response; response to interferon-alpha; innate immune response; negative regulation of viral transcription; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
	10410
	66141
	ENSG00000142089
	ENSMUSG00000025492
	Q01628
	Q9CQW9
	NM_021034
	NM_025378
	NP_066362
	NP_079654
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene.^[5]^[6]^[7] It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked.^[8] This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1.^[9] The prevalence of this mutation is thought to be approximately 1/400 in European populations.^[9]^[10]