IFNAR1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesIFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, interferon alpha and beta receptor subunit 1
Quick facts Available structures, PDB ...
IFNAR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, interferon alpha and beta receptor subunit 1
External IDsOMIM: 107450; MGI: 107658; HomoloGene: 524; GeneCards: IFNAR1; OMA:IFNAR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000629

NM_010508

RefSeq (protein)

NP_000620

NP_034638

Location (UCSC)Chr 21: 33.32 – 33.36 MbChr 16: 91.28 – 91.3 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons, including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.[6]

Interactions

IFNAR1 has been shown to interact with:

References

Further reading

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