IFNAR2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesIFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
Quick facts Available structures, PDB ...
IFNAR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
External IDsOMIM: 602376; MGI: 1098243; HomoloGene: 49242; GeneCards: IFNAR2; OMA:IFNAR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001110498
NM_010509
NM_001347258

RefSeq (protein)

NP_001103968
NP_001334187
NP_034639

Location (UCSC)Chr 21: 33.21 – 33.27 MbChr 16: 91.17 – 91.2 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[6]

Interactions

IFNAR2 has been shown to interact with:

References

Further reading

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