IFNAR2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[5]
AliasesIFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
External IDsOMIM: 602376; MGI: 1098243; HomoloGene: 49242; GeneCards: IFNAR2; OMA:IFNAR2 - orthologs
Function
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[6]