Interferon gamma receptor 1

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.^[5]

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.^[8][9]

Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections.^[10][11] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.^[12][13]

• Cluster of differentiation
• Interferon-gamma receptor