IFT81

IFT81
Identifiers
Aliases	IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs	OMIM: 605489; MGI: 1098597; HomoloGene: 7664; GeneCards: IFT81; OMA:IFT81 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	110,218,793 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,752,581 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; ventricular zone; ; right uterine tube; ; ganglionic eminence; ; Achilles tendon; ; olfactory zone of nasal mucosa; ; testicle; ; Epithelium of choroid plexus; ; left testis; ; right testis;
	Top expressed in
	spermatid; ; saccule; ; spermatocyte; ; neural layer of retina; ; interventricular septum; ; genital tubercle; ; otic vesicle; ; vestibular sensory epithelium; ; right ventricle; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	tubulin binding; protein binding;
Cellular component	intraciliary transport particle B; ciliary basal body; centrosome; sperm principal piece; cell projection; ciliary tip; motile cilium; sperm midpiece; cilium;
Biological process	cell projection organization; spermatogenesis; intraciliary transport; intraciliary transport involved in cilium assembly; cilium assembly; regulation of smoothened signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	28981
	12589
	ENSG00000122970
	ENSMUSG00000029469
	Q8WYA0
	O35594
NM_001143779; NM_014055; NM_031473; NM_001347946; NM_001347947;
	NM_001347948
	NM_009879; NM_001358917; NM_001358918; NM_001358919
NP_001137251; NP_054774; NP_113661; NP_001334875; NP_001334876;
	NP_001334877; NP_001137251.1; NP_054774.2
	NP_034009; NP_001345846; NP_001345847; NP_001345848
	Wikidata
View/Edit Human	View/Edit Mouse

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.^[5]^[6] Together with IFT74/72 it forms a core complex to build IFT particles^[7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170^[8] which regulates the disassembly of the cilium.