IL13RA2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesIL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
Quick facts Available structures, PDB ...
IL13RA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDsOMIM: 300130; MGI: 1277954; HomoloGene: 534; GeneCards: IL13RA2; OMA:IL13RA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000640

NM_008356
NM_001306059

RefSeq (protein)

NP_000631

NP_001292988
NP_032382

Location (UCSC)Chr X: 115 – 115.02 MbChr X: 146.17 – 146.21 Mb
PubMed search[3][4]
Wikidata
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Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[5]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas.[6][7][8][9]

See also

References

Further reading

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