IL18RAP
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[5][6]
AliasesIL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDsOMIM: 604509; MGI: 1338888; HomoloGene: 2859; GeneCards: IL18RAP; OMA:IL18RAP - orthologs
Function
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[5]
Disease association
Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[7]
