IL31RA

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.^[5][6][7]

AliasesIL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A, zcytoR17

External IDsOMIM: 609510; MGI: 2180511; HomoloGene: 51395; GeneCards: IL31RA; OMA:IL31RA - orthologs

Chr.Chromosome 5 (human)^[1]

End55,922,854 bp^[1]

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IL31RA
Identifiers
Aliases	IL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A, zcytoR17
External IDs	OMIM: 609510; MGI: 2180511; HomoloGene: 51395; GeneCards: IL31RA; OMA:IL31RA - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,851,357 bp[1] End 55,922,854 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 112,656,432 bp[2] End 112,730,894 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad monocyte thoracic aorta ascending aorta spinal ganglia Descending thoracic aorta granulocyte trigeminal ganglion tibia Top expressed in lumbar spinal ganglion zygote secondary oocyte primary oocyte seminal vesicula embryo spermatid morula ventricular zone Rostral migratory stream More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity cytokine receptor activity protein kinase binding cytokine binding Cellular component membrane external side of plasma membrane plasma membrane synapse cell junction integral component of membrane axon intracellular anatomical structure presynaptic membrane cell projection receptor complex Biological process defense response receptor signaling pathway via JAK-STAT transmembrane receptor protein tyrosine kinase signaling pathway cytokine-mediated signaling pathway immune system process defense response to other organism negative regulation of macrophage activation negative regulation of apoptotic process acute inflammatory response to antigenic stimulus monocyte differentiation macrophage differentiation MAPK cascade positive regulation of transcription, DNA-templated glandular epithelial cell differentiation positive regulation of cell population proliferation T-helper 2 cell cytokine production homeostatic process positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 133396 218624 Ensembl ENSG00000164509 ENSMUSG00000050377 UniProt Q8NI17 Q8K5B1 RefSeq (mRNA) NM_001242636 NM_001242637 NM_001242638 NM_001242639 NM_001297570 NM_001297572 NM_139017 NM_139299 RefSeq (protein) NP_001229565 NP_001229566 NP_001229567 NP_001229568 NP_001284499 NP_001284501 NP_620586 NP_647460 Location (UCSC) Chr 5: 55.85 – 55.92 Mb Chr 13: 112.66 – 112.73 Mb PubMed search [3] [4]
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IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]^[7]