ING3

Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesING3, Eaf4, ING2, MEAF4, p47inhibitor of growth family member 3

External IDsOMIM: 607493; MGI: 1919027; HomoloGene: 6804; GeneCards: ING3; OMA:ING3 - orthologs

Chr.Chromosome 7 (human)^[1]

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ING3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4I
Identifiers
Aliases	ING3, Eaf4, ING2, MEAF4, p47inhibitor of growth family member 3
External IDs	OMIM: 607493; MGI: 1919027; HomoloGene: 6804; GeneCards: ING3; OMA:ING3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.31 Start 120,950,763 bp[1] End 120,977,216 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.1 Start 21,949,570 bp[2] End 21,976,037 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone monocyte testicle Achilles tendon bone marrow tail of epididymis gonad germinal epithelium parietal pleura Top expressed in zygote secondary oocyte genital tubercle tail of embryo spermatid granulocyte primary oocyte Rostral migratory stream medial ganglionic eminence ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone acetyltransferase activity methylated histone binding metal ion binding Cellular component Piccolo NuA4 histone acetyltransferase complex nucleus nucleoplasm Swr1 complex NuA4 histone acetyltransferase complex Biological process histone H4 acetylation histone H2A acetylation regulation of growth regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of apoptotic process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54556 71777 Ensembl ENSG00000071243 ENSMUSG00000029670 UniProt Q9NXR8 Q8VEK6 RefSeq (mRNA) NM_198267 NM_019071 NM_198266 NM_023626 NM_001311061 RefSeq (protein) NP_061944 NP_938008 NP_001297990 NP_076115 Location (UCSC) Chr 7: 120.95 – 120.98 Mb Chr 6: 21.95 – 21.98 Mb PubMed search [3] [4]
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The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.^[6]