ING4
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[5][6]
External IDsOMIM: 608524; MGI: 107307; HomoloGene: 22952; GeneCards: ING4; OMA:ING4 - orthologs
Function
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[6]
