INSL4

Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene.^[3][4][5]

AliasesINSL4, EPIL, PLACENTIN, insulin like 4

External IDsOMIM: 600910; HomoloGene: 88662; GeneCards: INSL4; OMA:INSL4 - orthologs

Chr.Chromosome 9 (human)^[1]

End5,235,304 bp^[1]

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INSL4
Identifiers
Aliases	INSL4, EPIL, PLACENTIN, insulin like 4
External IDs	OMIM: 600910; HomoloGene: 88662; GeneCards: INSL4; OMA:INSL4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.1 Start 5,231,419 bp[1] End 5,235,304 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta gonad corpus epididymis stromal cell of endometrium cecum appendix liver smooth muscle tissue right lobe of liver popliteal artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding insulin-like growth factor receptor binding hormone activity Cellular component extracellular region extracellular space Biological process multicellular organism development female pregnancy cell-cell signaling cell population proliferation signal transduction regulation of signaling receptor activity positive regulation of chorionic trophoblast cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3641 n/a Ensembl ENSG00000120211 n/a UniProt Q14641 n/a RefSeq (mRNA) NM_002195 n/a RefSeq (protein) NP_002186 n/a Location (UCSC) Chr 9: 5.23 – 5.24 Mb n/a PubMed search [2] n/a
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INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.^[5]