IQGAP2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesIQGAP2, IQ motif containing GTPase activating protein 2
Quick facts Available structures, PDB ...
IQGAP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIQGAP2, IQ motif containing GTPase activating protein 2
External IDsOMIM: 605401; MGI: 2449975; HomoloGene: 101543; GeneCards: IQGAP2; OMA:IQGAP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001285460
NM_001285461
NM_001285462
NM_006633

NM_027711

RefSeq (protein)

NP_001272389
NP_001272390
NP_001272391
NP_006624

NP_081987

Location (UCSC)Chr 5: 76.4 – 76.71 MbChr 13: 95.76 – 96.03 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[6]

Interactions

IQGAP2 has been shown to interact with CDC42[5] and RAC1.[5]

References

Further reading

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