IRAK2

IRAK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MOP
Identifiers
Aliases	IRAK2, IRAK-2, interleukin 1 receptor associated kinase 2
External IDs	OMIM: 603304; MGI: 2429603; HomoloGene: 1207; GeneCards: IRAK2; OMA:IRAK2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	10,243,745 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	113,671,987 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; pancreatic epithelial cell; ; secondary oocyte; ; pancreatic ductal cell; ; palpebral conjunctiva; ; gastrocnemius muscle; ; tibialis anterior muscle; ; amniotic fluid; ; endothelial cell; ; islet of Langerhans;
	Top expressed in
	granulocyte; ; jejunum; ; urinary bladder; ; white adipose tissue; ; spleen; ; left lung; ; colon; ; proximal tubule; ; duodenum; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; protein homodimerization activity; protein serine/threonine kinase activity; protein binding; protein heterodimerization activity; ATP binding;
Cellular component	cytoplasm; cytosol; plasma membrane; endosome membrane; nucleus;
Biological process	response to interleukin-1; negative regulation of DNA-binding transcription factor activity; toll-like receptor signaling pathway; protein phosphorylation; JNK cascade; positive regulation of NF-kappaB transcription factor activity; toll-like receptor 9 signaling pathway; negative regulation of NF-kappaB transcription factor activity; nucleotide-binding oligomerization domain containing signaling pathway; lipopolysaccharide-mediated signaling pathway; signal transduction; regulation of cytokine-mediated signaling pathway; I-kappaB kinase/NF-kappaB signaling; inflammatory response; MyD88-dependent toll-like receptor signaling pathway; intracellular signal transduction; interleukin-1-mediated signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3656
	108960
	ENSG00000134070
	ENSMUSG00000060477
	O43187
	Q8CFA1
	NM_001570
	NM_001113553; NM_172161
	NP_001561
	NP_001107025; NP_751893
	Wikidata
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