IRAK3

Interleukin-1 receptor-associated kinase 3 (originally IRAK-M) is an enzyme that in humans is encoded by the IRAK3 gene.^[5][6] The IRAK family of proteins consists of two active serine/threonine kinases IRAK-1 and IRAK-4, as well as two inactive kinases IRAK-2 and IRAK-3. The activity of IRAK-3 is induced by toll-like receptor and interleukin-1 receptor signaling. IRAK-3 acts as a negative regulator for downstream signaling through these pathways by preventing the phosphorylation of IRAK-1 and IRAK-4 or by inhibiting their dissociation from the Mydd88 complex. ^[7] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.^[8]

AliasesIRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3

External IDsOMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs

Chr.Chromosome 12 (human)^[1]

End66,254,622 bp^[1]

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IRAK3
Identifiers
Aliases	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs	OMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3 Start 66,189,195 bp[1] End 66,254,622 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 119,977,553 bp[2] End 120,038,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte bone marrow parietal pleura blood right lung bone marrow cell palpebral conjunctiva spleen lower lobe of lung trabecular bone Top expressed in granulocyte gastrula spermatocyte seminiferous tubule spermatid bone marrow ankle sciatic nerve lip blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity transferase activity magnesium ion binding protein serine/threonine kinase activity kinase activity protein homodimerization activity protein heterodimerization activity ATP binding protein binding Cellular component cytoplasm nucleus plasma membrane Biological process response to lipopolysaccharide negative regulation of innate immune response signal transduction negative regulation of macrophage cytokine production protein autophosphorylation negative regulation of protein-containing complex disassembly response to interleukin-1 response to exogenous dsRNA protein phosphorylation negative regulation of toll-like receptor signaling pathway cytokine-mediated signaling pathway response to virus response to peptidoglycan negative regulation of cytokine-mediated signaling pathway regulation of protein-containing complex disassembly positive regulation of macrophage tolerance induction negative regulation of NF-kappaB transcription factor activity phosphorylation negative regulation of protein catabolic process negative regulation of interleukin-6 production interleukin-1-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity negative regulation of MAP kinase activity negative regulation of tumor necrosis factor production negative regulation of interleukin-12 production MyD88-dependent toll-like receptor signaling pathway intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11213 73914 Ensembl ENSG00000090376 ENSMUSG00000020227 UniProt Q9Y616 Q8K4B2 RefSeq (mRNA) NM_007199 NM_001142523 NM_028679 NM_001359184 RefSeq (protein) NP_001135995 NP_009130 NP_082955 NP_001346113 Location (UCSC) Chr 12: 66.19 – 66.25 Mb Chr 10: 119.98 – 120.04 Mb PubMed search [3] [4]
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