IRF2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesIRF2, IRF-2, interferon regulatory factor 2
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IRF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIRF2, IRF-2, interferon regulatory factor 2
External IDsOMIM: 147576; MGI: 96591; HomoloGene: 1659; GeneCards: IRF2; OMA:IRF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002199

NM_008391

RefSeq (protein)

NP_002190

NP_032417

Location (UCSC)Chr 4: 184.39 – 184.47 MbChr 8: 47.19 – 47.3 Mb
PubMed search[3][4]
Wikidata
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Function

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[6]

See also

Interactions

IRF2 has been shown to interact with BRD7,[7] EP300[8] and PCAF.[8][9]

References

Further reading

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