IRGM

Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is encoded by the IRGM gene.^[5]

AliasesIRGM, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M, immunity related GTPase M

External IDsOMIM: 608212; MGI: 1926262; HomoloGene: 78363; GeneCards: IRGM; OMA:IRGM - orthologs

Chr.Chromosome 5 (human)^[1]

End150,900,736 bp^[1]

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IRGM
Identifiers
Aliases	IRGM, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M, immunity related GTPase M
External IDs	OMIM: 608212; MGI: 1926262; HomoloGene: 78363; GeneCards: IRGM; OMA:IRGM - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,846,521 bp[1] End 150,900,736 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,090,444 bp[2] End 58,113,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle granulocyte Achilles tendon appendix lymph node stromal cell of endometrium blood smooth muscle tissue gallbladder Top expressed in mesenteric lymph nodes mucous cell of stomach Paneth cell left lobe of liver lumbar spinal ganglion spleen iris subcutaneous adipose tissue ciliary body blood More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding hydrolase activity protein binding protein kinase binding protein serine/threonine kinase activator activity CARD domain binding BH3 domain binding GTPase activity Cellular component phagocytic vesicle membrane autophagosome membrane cell projection phagocytic cup plasma membrane membrane cytoplasmic vesicle Golgi membrane mitochondrion Golgi apparatus cytosol endoplasmic reticulum membrane Biological process autophagy inflammatory response immune system process autophagosome assembly positive regulation of protein phosphorylation positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein destabilization positive regulation of peptidyl-serine phosphorylation regulation of protein-containing complex assembly innate immune response protein stabilization defense response to Gram-negative bacterium positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide positive regulation of autophagosome maturation positive regulation of protein serine/threonine kinase activity defense response cellular response to interferon-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 345611 54396 Ensembl ENSG00000237693 ENSMUSG00000069874 UniProt A1A4Y4 Q9Z1M2 RefSeq (mRNA) NM_001145805 NM_001346557 NM_019440 RefSeq (protein) NP_001139277 NP_001333486 n/a Location (UCSC) Chr 5: 150.85 – 150.9 Mb Chr 11: 58.09 – 58.11 Mb PubMed search [3] [4]
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IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.

The gene has been disabled by an Alu element for at least 25 million years in the primate lineage leading to great apes including humans, but it was re-enabled by an endogenous retrovirus called ERV-9.^[6]