ITIH2

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.^[5][6][7]

AliasesITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2

External IDsOMIM: 146640; MGI: 96619; HomoloGene: 1668; GeneCards: ITIH2; OMA:ITIH2 - orthologs

Chr.Chromosome 10 (human)^[1]

End7,749,520 bp^[1]

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ITIH2
Identifiers
Aliases	ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
External IDs	OMIM: 146640; MGI: 96619; HomoloGene: 1668; GeneCards: ITIH2; OMA:ITIH2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p14 Start 7,703,316 bp[1] End 7,749,520 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A1|2 6.89 cM Start 10,099,404 bp[2] End 10,136,207 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver testicle Epithelium of choroid plexus tibialis anterior muscle cerebellar hemisphere putamen right hemisphere of cerebellum prefrontal cortex pancreatic ductal cell Top expressed in left lobe of liver gallbladder fetal liver hematopoietic progenitor cell human fetus vestibular membrane of cochlear duct ankle joint abdominal wall sexually immature organism ascending aorta optic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component blood microparticle extracellular exosome extracellular region endoplasmic reticulum lumen collagen-containing extracellular matrix Biological process hyaluronan metabolic process negative regulation of peptidase activity negative regulation of endopeptidase activity post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3698 16425 Ensembl ENSG00000151655 ENSMUSG00000037254 UniProt P19823 Q61703 RefSeq (mRNA) NM_002216 NM_010582 RefSeq (protein) NP_002207 NP_034712 Location (UCSC) Chr 10: 7.7 – 7.75 Mb Chr 2: 10.1 – 10.14 Mb PubMed search [3] [4]
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It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.