ITM2B

Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the ITM2B gene.^[5][6]

AliasesITM2B, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2, RDGCA, integral membrane protein 2B

External IDsOMIM: 603904; MGI: 1309517; HomoloGene: 7388; GeneCards: ITM2B; OMA:ITM2B - orthologs

Chr.Chromosome 13 (human)^[1]

End48,270,357 bp^[1]

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ITM2B
Identifiers
Aliases	ITM2B, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2, RDGCA, integral membrane protein 2B
External IDs	OMIM: 603904; MGI: 1309517; HomoloGene: 7388; GeneCards: ITM2B; OMA:ITM2B - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.2 Start 48,232,612 bp[1] End 48,270,357 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D3|14 38.88 cM Start 73,599,666 bp[2] End 73,622,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus corpus epididymis germinal epithelium kidney tubule visceral pleura jejunal mucosa renal medulla parietal pleura caput epididymis Top expressed in stroma of bone marrow vestibular sensory epithelium skin of external ear molar lobe of prostate transitional epithelium of urinary bladder right lung calvaria right lung lobe efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amyloid-beta binding protein binding ATP binding Cellular component integral component of organelle membrane extracellular region integral component of membrane Golgi-associated vesicle membrane Golgi membrane endosome plasma membrane Golgi apparatus endosome membrane extracellular exosome membrane intracellular membrane-bounded organelle extracellular space Biological process nervous system development negative regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9445 16432 Ensembl ENSG00000136156 ENSMUSG00000022108 UniProt Q9Y287 O89051 RefSeq (mRNA) NM_021999 NM_008410 RefSeq (protein) NP_068839 NP_032436 Location (UCSC) Chr 13: 48.23 – 48.27 Mb Chr 14: 73.6 – 73.62 Mb PubMed search [3] [4]
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ITM2B or BRI2 is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.