Ibogamine
Anti-convulsant, anti-addictive CNS stimulant alkaloid
From Wikipedia, the free encyclopedia
Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata).[1][2][3] Basic research related to how addiction affects the brain has used this chemical.[4]
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| Formula | C19H24N2 |
| Molar mass | 280.415 g·mol−1 |
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Pharmacology
Like ibogaine, it has seems to have similar pharmacology. It has effects on KOR,[5] NMDAR, nAChR[6] and serotonin sites.[7] It also inhibits acetylcholinesterase and butyrylcholinesterase.[8]
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[9] The same study found that ibogamine (40 mg/kg) and coronaridine (40 mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids ibogaine (20–40 mg/kg), harmaline (10–40 mg/kg) and desethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".[9]
Chemistry
Synthesis
Ibogamine can be prepared from one-step demethoxycarbonylation process through coronaridine.[10]