IgSF CAM
Cell adhesion molecules in the immunoglobulin superfamily
From Wikipedia, the free encyclopedia
IgSF CAMs (Immunoglobulin-like Cell Adhesion Molecules) are cell adhesion molecules that belong to Immunoglobulin superfamily.[1] It is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI moiety. This family is involved in both homophilic or heterophilic binding and has the ability to bind integrins or different IgSF CAMs.
SymbolIgSF CAM
| Immunoglobulin-like adhesion molecules | |
|---|---|
| Identifiers | |
| Symbol | IgSF CAM |
| Membranome | 221 |
Examples
Here is a list of some molecules of this family:
- NCAMs Neural Cell Adhesion Molecules
- ICAM-1 Intercellular Cell Adhesion Molecule
- VCAM-1 Vascular Cell Adhesion Molecule
- PECAM-1 Platelet-endothelial Cell Adhesion Molecule
- MAdCAM-1 Mucosal Vascular Addressin Cell Adhesion Molecule
- L1 family including L1 (protein), CHL1, Neurofascin and NrCAM
- SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83
- CTX family including CTX, Junctional adhesion molecule (JAM), BT-IgSF, Coxsackie virus and adenovirus receptor (CAR), VSIG, ESAM
- Nectins and related proteins, including CADM1 and other Synaptic Cell Adhesion Molecules
- CD2
- CD48
- HEPACAM
- HEPACAM2
- DSCAM - Down syndrome cell adhesion molecule