Ignavine
Diterpine alkaloid and opioid receptor modulator
From Wikipedia, the free encyclopedia
Ignavine is a naturally occurring diterpene alkaloid found in Aconiti tuber.[1][2][3][4][5] It has been reported to act as a μ-opioid receptor (MOR) positive allosteric modulator (PAM).[1][3][4][6] The drug potentiated responses to the selective MOR agonist DAMGO at low concentrations but inhibited DAMGO at high concentrations.[1][4][6] Ignavine alone has been found to produce analgesic effects in animals, but with a biphasic dose–response curve.[4][1] Although described as a MOR PAM, other research suggests that ignavine is a ligand of the orthosteric site of the MOR and does not act as a PAM.[1] Instead, it may be a MOR partial agonist.[1] However, more research is necessary to clarify its MOR actions.[1] Ignavine was first isolated by 1952[5] and its reported MOR PAM activity was first reported by 2016.[2][6]
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| Other names | 3,9,15-Trihydroxyhetisan-2-yl benzoate |
| Drug class | μ-Opioid receptor positive allosteric modulator or agonist; Analgesic |
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| Formula | C27H31NO5 |
| Molar mass | 449.547 g·mol−1 |
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