Intepirdine

Chemical compound From Wikipedia, the free encyclopedia

Intepirdine (INN; developmental codes SB-742457, RVT-101)[1] is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.[2][3] It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease and demonstrated some preliminary efficacy in phase II clinical trials.[3] GSK chose not to continue development and sold the rights to Axovant Sciences for $5 million in December 2014.[4]

Other namesSB-742457, RVT-101
Routes of
administrationOral
ATC code
  • none
Legal status
  • Investigational/abandoned
Quick facts Clinical data, Other names ...
Intepirdine
Clinical data
Other namesSB-742457, RVT-101
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • Investigational/abandoned
Identifiers
  • 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.158.094 Edit this at Wikidata
Chemical and physical data
FormulaC19H19N3O2S
Molar mass353.44 g·mol−1
3D model (JSmol)
  • C3CNCCN3c1cccc(c1nc4)cc4S(=O)(=O)c2ccccc2
  • InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2 ☒N
  • Key:JJZFWROHYSMCMU-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)
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Results of a phase III clinical trial for the treatment of Alzheimer's disease were reported in September 2017.[5] The trial showed no improvement over control group and Axovant lost 70% of its value upon the announcement of the trial results.[6]

Intepirdine also entered clinical trials for dementia with Lewy bodies, also with negative results.[7] Consequently, Axovant announced in 2018 that it has discontinued development of this drug.[7]

References

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