Intercellular adhesion molecule
Protein domain
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In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.
| Intercellular adhesion molecule (ICAM), N-terminal domain | |||||||
|---|---|---|---|---|---|---|---|
structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1 | |||||||
| Identifiers | |||||||
| Symbol | ICAM_N | ||||||
| Pfam | PF03921 | ||||||
| Pfam clan | CL0159 | ||||||
| InterPro | IPR013768 | ||||||
| SCOP2 | 1zxq / SCOPe / SUPFAM | ||||||
| Membranome | 219 | ||||||
| |||||||
Mammalian intercellular adhesion molecules include:
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