Ipriflavone

Ipriflavone (INN, JAN; brand name Yambolap) is a synthetic isoflavone which may be used to inhibit bone resorption,^[2] maintain bone density and to prevent osteoporosis in postmenopausal women.^[1] It is not used to treat osteoporosis. It slows down the action of the osteoclasts (bone-eroding cells), possibly allowing the osteoblasts (bone-building cells) to build up bone mass.

Trade namesYambolap

Other namesFLI13; 7-Isopropoxyisoflavone^[1]

AHFS/Drugs.comInternational Drug Names

ATC code

• M05BX01 (WHO)

Quick facts Clinical data, Trade names ...

Ipriflavone

Clinical data
Trade names	Yambolap
Other names	FLI13; 7-Isopropoxyisoflavone[1]
AHFS/Drugs.com	International Drug Names
ATC code	M05BX01 (WHO)
Legal status
Legal status	US: Not FDA approved Rx-only in Japan
Identifiers
IUPAC name 7-Isopropoxy-3-phenyl-4H-chromen-4-one
CAS Number	35212-22-7 N
PubChem CID	3747
ChemSpider	3616 N
UNII	80BJ7WN25Z
KEGG	D01338 Y
ChEMBL	ChEMBL165790 N
CompTox Dashboard (EPA)	DTXSID5040679
ECHA InfoCard	100.125.854
Chemical and physical data
Formula	C18H16O3
Molar mass	280.323 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)OC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=CC=C3
InChI InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3 N Key:SFBODOKJTYAUCM-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Close

A clinical trial reported in 2001 that it was not effective in prevention or treatment of osteoporosis.^[3]

A double-blind study reveals that ipriflavone might be effective on reducing tinnitus on otosclerosis sufferers.^[4]

Ipriflavone has been described as a phytoestrogen.^[5] However, this is incorrect, as the drug does not bind to or activate the estrogen receptor and shows no estrogenic effects in postmenopausal women.^[6][7] The drug prevents bone loss via mechanisms that are distinct from those of estrogens.^[5]