Iso-THIP

Iso-THIP
Clinical data
Other names	IsoTHIP; Isogaboxadol
Drug class	GABAA-ρ receptor antagonist; GABAA receptor antagonist
ATC code	None;
Identifiers
	IUPAC name 4,5,6,7-tetrahydro-1H-[1,2]oxazolo[3,4-c]pyridin-3-one;
CAS Number	71233-27-7;
PubChem CID	130546;
ChemSpider	115482;
CompTox Dashboard (EPA)	DTXSID20991542 ;
Chemical and physical data
Formula	C6H8N2O2
Molar mass	140.142 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CNCC2=C1C(=O)ON2;
	InChI InChI=1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)8-10-6/h7-8H,1-3H2; Key:HTKHYLOBQZWEFD-UHFFFAOYSA-N;

Iso-THIP, or isoTHIP, is a selective and potent GABA_A-ρ receptor (GABA_C receptor) antagonist related to gaboxadol (THIP).^[1]^[2]^[3] It is 4-fold more potent than gaboxadol as a GABA_A-ρ receptor antagonist.^[2]^[3] In addition to its GABA_A-ρ receptor antagonism, iso-THIP shows much lower but still detectable affinity for the GABA_A receptor, where it appears to be an antagonist similarly.^[2]^[3]^[4] The drug was first described in the scientific literature by Povl Krogsgaard-Larsen and colleagues by 1979.^[4]^[5]