Isometheptene

Sympathomimetic amine From Wikipedia, the free encyclopedia

Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins).[1][2]

AHFS/Drugs.comInternational Drug Names
MedlinePlusa601064
Routes of
administrationOral
ATC code
Quick facts Clinical data, AHFS/Drugs.com ...
Isometheptene
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa601064
Routes of
administration		Oral
ATC code
Identifiers
  • N,6-Dimethylhept-5-en-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.007.236 Edit this at Wikidata
Chemical and physical data
FormulaC9H19N
Molar mass141.258 g·mol−1
3D model (JSmol)
  • CNC(C)CCC=C(C)C
  • InChI=1S/C9H19N/c1-8(2)6-5-7-9(3)10-4/h6,9-10H,5,7H2,1-4H3 checkY
  • Key:XVQUOJBERHHONY-UHFFFAOYSA-N checkY
  (verify)
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Mechanism of action

Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.[3]

See also

References

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