JWH-138
Chemical compound
From Wikipedia, the free encyclopedia
JWH-138 (Δ8-THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesized by Roger Adams and later studied by John W. Huffman, with a Ki of 8.5nM at the CB1 cannabinoid receptor.[1]
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| Formula | C24H36O2 |
| Molar mass | 356.550 g·mol−1 |
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Δ9-THC-Octyl and its hydrogenated analog HHC-Octyl was synthesized and studied by Roger Adams as early as 1942,[2] and should not be confused with the Δ8 analog.
Isomers
The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be slightly less active than Δ3-THC itself.[3] The alternate isomer Δ9-THC-C8 has also been synthesised,[4].
Tetrahydrocannabioctyl is sometimes referred to as THC-Octyl or THC-O, which may cause confusion with THC-O-acetate which is commonly known as THC-O on packaging for grey market vaping liquids sold for use in humans. Both Δ8 and Δ9 (C8)-THC have been sold as designer drugs, first identified in Denmark in August 2024.[5]
Legality
Both the Δ8 and Δ9 isomers are included within the definition of an "intoxicating cannabinoid" in Colorado under the name tetrahydrocannabioctyl,[6] but it is unclear if it has been identified as a natural product.
