List of JWH cannabinoids

Substances synthesized by John W. Huffman's research group From Wikipedia, the free encyclopedia

The John W. Huffman research group at Clemson University synthesized over 450 cannabinoids.[1][2][3][4] Some of those are:

More information Name, Class ...
Cannabinoids and their Ki values[a]
Name Class Ki / nM at CB1 Ki / nM at CB2 Selectivity Structure
JWH-004Naphthoylindole48 ± 134 ± 1.5CB2 (12x)
JWH-007[5]Naphthoylindole9.5 ± 4.52.9 ± 2.6CB2 (3.3x)
JWH-009Naphthoylindole>10000141 ± 14CB2 (>70x)
JWH-011Naphthoylindole
JWH-015[5]Naphthoylindole164 ± 2213.8 ± 4.6CB2 (12x)
JWH-016Naphthoylindole22 ± 1.54.3 ± 1.6CB2 (5.1x)
JWH-018[5]Naphthoylindole9 ± 52.9 ± 2.6CB2 (3.1x)
JWH-019Naphthoylindole9.8 ± 25.55 ± 2CB2 (1.77x)
JWH-020Naphthoylindole128 ± 17205 ± 20CB1 (1.6x)
JWH-030Naphthoylpyrrole87 ± 3320 ± 127CB1 (3.7x)
JWH-031Naphthoylpyrrole399 ± 109
JWH-032Naphthoylpyrrole>10000>10000—
JWH-033Naphthoylpyrrole666 ± 77
JWH-036Naphthoylpyrrole309 ± 11
JWH-042[6] Naphthoylindole>100005050 ± 192CB2
JWH-043[6]Naphthoylindole1180 ± 44964 ± 242CB2 (1.2x)
JWH-044Naphthoylpyrrole>10000>10000—
JWH-045Naphthoylpyrrole>10000>10000—
JWH-046[6]Naphthoylindole343 ± 3816.3 ± 4.9CB2 (21x)
JWH-047[6]Naphthoylindole59 ± 33.47 ± 1.80CB2 (17x)
JWH-048[6]Naphthoylindole10.7 ± 1.00.49 ± 0.13CB2 (22x)
JWH-049[6]Naphthoylindole55.1 ± 17.032.3 ± 2.4CB2 (1.7x)
JWH-050[6]Naphthoylindole342 ± 6526 ± 133CB1 (1.5x)
JWH-051Dibenzopyran1.200.03CB2 (40x)
JWH-056[7]Dibenzopyran>1000032 ± 9CB2
JWH-057[8]Dibenzopyran23 ± 72.9 ± 1.6CB2 (8x)
JWH-065[7]Dibenzopyran399 ± 7610 ± 2CB2 (40x)
JWH-070[6]Naphthoylindole>10000>10000
JWH-071[6]Naphthoylindole1340 ± 1232940 ± 852CB1 (2.2x)
JWH-072Naphthoylindole1050 ± 5.5170 ± 54CB2 (6x)
JWH-073Naphthoylindole8.9 ± 1.827 ± 12CB1 (3x)
JWH-076[5]Naphthoylindole214 ± 11106 ± 46CB2 (2x)
JWH-077[6]Naphthoylindole>10000>10000
JWH-078[6]Naphthoylindole817 ± 60633 ± 116CB2 (1.3x)
JWH-079[6]Naphthoylindole63.0 ± 3.032.0 ± 6.0CB2 (2x)
JWH-080[6]Naphthoylindole8.9 ± 1.82.21 ± 1.30CB2 (4x)
JWH-081[6]Naphthoylindole1.2 ± 0.0312.4 ± 2.2CB1 (10x)
JWH-082[6]Naphthoylindole5.3 ± 0.86.40 ± 0.94CB1 (1.2x)
JWH-083[6]Naphthoylindole106 ± 12102 ± 50—
JWH-091[9] (Δ8-THCP)Dibenzopyran22.0 ± 3.9
JWH-093[6]Naphthoylindole40.7 ± 2.859.1 ± 10.5CB1 (1.45x)
JWH-094[6]Naphthoylindole476 ± 6797.3 ± 2.7CB2 (4.9x)
JWH-095[6]Naphthoylindole140 ± 4.3312 ± 83CB1 (2.2x)
JWH-096[6]Naphthoylindole33.7 ± 2.913.3 ± 5.6CB2 (2.5x)
JWH-097[6]Naphthoylindole455 ± 28121 ± 15CB2 (3.8x)
JWH-098[6]Naphthoylindole4.5 ± 0.11.9 ± 0.3CB2 (2.4x)
JWH-099[6]Naphthoylindole35.3 ± 9.017.8 ± 2.9CB2 (2x)
JWH-100[6]Naphthoylindole381 ± 102155 ± 74CB2 (2.5x)
JWH-102[7]Dibenzopyran7.9 ± 0.95.2 ± 2.0CB2 (1.5x)
JWH-103[7]Dibenzopyran28 ± 323 ± 7CB2 (1.2x)
JWH-116[10]Naphthoylindole52 ± 5
JWH-120[5]Naphthoylindole1054 ± 316.1 ± 0.7CB2 (173x)
JWH-122[10]Naphthoylindole0.69 ± 0.051.2 ± 1.2—
JWH-124 (Δ8-Parahexyl)Dibenzopyran41.0 ± 3.8
JWH-130 (Δ8-THCB)Dibenzopyran65.0 ± 13
JWH-133[7]Dibenzopyran677 ± 1323.4 ± 1.0CB2 (200x)
JWH-138[11]Dibenzopyran8.5 ± 1.4
JWH-139[12]Dibenzopyran2290 ± 50514 ± 10CB2 (164x)
JWH-142[7]Dibenzopyran529 ± 4935 ± 14CB2 (15x)
JWH-143[7]Dibenzopyran924 ± 10465 ± 8CB2 (14x)
JWH-145[13]Naphthoylpyrrole14 ± 26.4 ± 0.4CB2 (2.2x)
JWH-146[13]Naphthoylpyrrole21 ± 262 ± 5CB2 (3.0x)
JWH-147[13]Naphthoylpyrrole11 ± 17.1 ± 0.2CB2 (1.5x)
JWH-148[5]Naphthoylindole123 ± 814.0 ± 1.0CB2 (8x)
JWH-149[5]Naphthoylindole5.0 ± 2.10.73 ± 0.03CB2 (6.8x)
JWH-150[13]Naphthoylpyrrole60 ± 115 ± 2CB2 (4x)
JWH-151[5]Naphthoylindole>1000030 ± 1.1CB2 (>333x)
JWH-153[5]Naphthoylindole250 ± 2411 ± 0.5CB2 (23x)
JWH-156[13]Naphthoylpyrrole404 ± 18104 ± 18CB2 (4x)
JWH-159[5]Naphthoylindole45 ± 110.4 ± 1.4CB2 (4.3x)
JWH-160[5]Naphthoylindole1568 ± 201441 ± 110CB2 (3.6x)
JWH-161Dibenzopyran hybrid19.0
JWH-163[5]Naphthoylindole2358 ± 215138 ± 12CB2 (17x)
JWH-164[5]Naphthoylindole6.6 ± 0.76.9 ± 0.2—
JWH-165[5]Naphthoylindole204 ± 2671 ± 8CB2 (2.9x)
JWH-166[5]Naphthoylindole44 ± 101.9 ± 0.08CB2 (23x)
JWH-167Phenylacetylindole90 ± 17159 ± 14CB1 (1.77x)
JWH-171Hydrocarbon51
JWH-175[10]Naphthylmethylindole22 ± 2
JWH-176[10]Hydrocarbon26 ± 4
JWH-180[5]Naphthoylindole26 ± 29.6 ± 2.0CB2 (2.7x)
JWH-181[5]Naphthoylindole1.3 ± 0.10.62 ± 0.04CB2 (2.1x)
JWH-182[5]Naphthoylindole0.65 ± 0.031.1 ± 0.1CB1 (1.7x)
JWH-184[10]Naphthylmethylindole23 ± 6
JWH-185[10]Naphthylmethylindole17 ± 3
JWH-186[14]Dibenzopyran187 ± 235.6 ± 1.7CB2 (33x)
JWH-187[14]Dibenzopyran84 ± 163.4 ± 0.5CB2 (25x)
JWH-188[14]Dibenzopyran270 ± 5818 ± 2CB2 (15x)
JWH-189[5]Naphthoylindole52 ± 212 ± 0.8CB2 (4.3x)
JWH-190[14]Dibenzopyran8.8 ± 1.41.6 ± 0.03CB2 (5.5x)
JWH-191[14]Dibenzopyran1.8 ± 0.30.52 ± 0.03CB2 (3.5x)
JWH-192[10]Naphthylmethylindole41 ± 13
JWH-193[10]Naphthoylindole6 ± 1
JWH-194[10]Naphthylmethylindole127 ± 19
JWH-195[10]Naphthylmethylindole113 ± 28
JWH-196[10]Naphthylmethylindole151 ± 18
JWH-197[10]Naphthylmethylindole323 ± 98
JWH-198[10]Naphthoylindole10 ± 2
JWH-199[10]Naphthylmethylindole20 ± 2
JWH-200[10]Naphthoylindole42 ± 5
JWH-201[15]Phenylacetylindole1064 ± 21444 ± 14CB2 (2.4x)
JWH-202[15]Phenylacetylindole1678 ± 63645 ± 6CB2 (2.6x)
JWH-203[15]Phenylacetylindole8.0 ± 0.97.0 ± 1.3—
JWH-204[15]Phenylacetylindole13 ± 125 ± 1CB1 (1.9x)
JWH-205[15]Phenylacetylindole124 ± 23180 ± 9CB1 (1.45x)
JWH-206[15]Phenylacetylindole389 ± 25498 ± 37CB1 (1.28x)
JWH-207[15]Phenylacetylindole1598 ± 1343723 ± 10CB1 (2.33x)
JWH-208[15]Phenylacetylindole179 ± 7570 ± 127CB1 (3.18x)
JWH-209[15]Phenylacetylindole746 ± 491353 ± 270CB1 (1.81x)
JWH-210[5]Naphthoylindole0.46 ± 0.030.69 ± 0.01CB1 (1.5x)
JWH-211[5]Naphthoylindole70 ± 0.812 ± 0.8CB2 (5.8x)
JWH-212[5]Naphthoylindole33 ± 0.910 ± 1.2CB2 (3.3x)
JWH-213[5]Naphthoylindole1.5 ± 0.20.42 ± 0.05CB2 (3.6x)
JWH-215[14]Dibenzopyran1008 ± 11785 ± 21CB2 (12x)
JWH-216[14]Dibenzopyran1856 ± 148333 ± 104CB2 (5.6x)
JWH-217[14]Dibenzopyran>100001404 ± 66CB2 (>7x)
JWH-220Hydrocarbon19
JWH-224[14]Dibenzopyran347 ± 3428 ± 1CB2 (12.3x)
JWH-225[14]Dibenzopyran>10000325 ± 70CB2 (>31x)
JWH-226[14]Dibenzopyran4001 ± 28243 ± 3CB2 (93x)
JWH-227[14]Dibenzopyran40 ± 64.4 ± 0.3CB2 (9x)
JWH-229[16]Dibenzopyran3134 ± 11018 ± 2CB2 (174x)
JWH-230[14]Dibenzopyran15 ± 31.4 ± 0.12CB2 (10.7x)
JWH-233[14]Dibenzopyran14 ± 31.0 ± 0.3CB2 (14x)
JWH-234[5]Naphthoylindole8.4 ± 1.83.8 ± 0.6CB2 (2.2x)
JWH-235[5]Naphthoylindole338 ± 34123 ± 34CB2 (2.7x)
JWH-236[5]Naphthoylindole1351 ± 204240 ± 63CB2 (5.6x)
JWH-237[15]Phenylacetylindole38 ± 10106 ± 2CB1 (2.8x)
JWH-239[5]Naphthoylindole342 ± 2052 ± 6CB2 (6.6x)
JWH-240[5]Naphthoylindole14 ± 17.2 ± 1.3CB2 (1.9x)
JWH-241[5]Naphthoylindole147 ± 2049 ± 7CB2 (3.0x)
JWH-242[5]Naphthoylindole42 ± 96.5 ± 0.3CB2 (6.5x)
JWH-243[13]Naphthoylpyrrole285 ± 4041 ± 3CB2 (6.95x)
JWH-244[13]Naphthoylpyrrole130 ± 618 ± 1CB2 (7.22x)
JWH-245[13]Naphthoylpyrrole276 ± 425 ± 2CB2 (11x)
JWH-246[13]Naphthoylpyrrole70 ± 416 ± 1CB2 (4.38x)
JWH-247[14]Dibenzopyran427 ± 3199 ± 4CB2 (4.3x)
JWH-248[15]Phenylacetylindole1028 ± 39657 ± 19CB2 (1.56x)
JWH-249[15]Phenylacetylindole8.4 ± 1.820 ± 2CB1 (2.38x)
JWH-250[15]Phenylacetylindole11 ± 233 ± 2CB1 (3x)
JWH-251[15]Phenylacetylindole29 ± 3146 ± 36CB2 (5x)
JWH-252[15]Phenylacetylindole23 ± 319 ± 1CB2 (1.2x)
JWH-253[15]Phenylacetylindole62 ± 1084 ± 12CB1 (1.35x)
JWH-254[14]Dibenzopyran4724 ± 509319 ± 16CB2 (14.8x)
JWH-256[14]Dibenzopyran4300 ± 88897 ± 18CB2 (44x)
JWH-258[5]Naphthoylindole4.6 ± 0.610.5 ± 1.3CB1 (2.3x)
JWH-259[5]Naphthoylindole220 ± 2974 ± 7CB2 (3.0x)
JWH-260[5]Naphthoylindole29 ± 0.425 ± 1.9CB2 (1.2x)
JWH-261[5]Naphthoylindole767 ± 105221 ± 14CB2 (3.5x)
JWH-262[5]Naphthoylindole28 ± 35.6 ± 0.7CB2 (5.0x)
JWH-265[5]Naphthoylindole3788 ± 32380 ± 13CB2 (47x)
JWH-266[5]Naphthoylindole>10000455 ± 55CB2 (>22x)
JWH-267[5]Naphthoylindole381 ± 167.2 ± 0.14CB2 (53x)
JWH-268[5]Naphthoylindole1379 ± 19340 ± 0.6CB2 (34x)
JWH-277[14]Dibenzopyran3905 ± 91589 ± 65CB2 (6.6x)
JWH-278[14]Dibenzopyran906 ± 8069 ± 6CB2 (13x)
JWH-292[13]Naphthoylpyrrole29 ± 120 ± 1CB2 (1.45x)
JWH-293[13]Naphthoylpyrrole100 ± 541 ± 4CB2 (2.44x)
JWH-298[14]Dibenzopyran812 ± 67198 ± 23CB2 (4.1x)
JWH-299[14]Dibenzopyran415 ± 5030 ± 2CB2 (13.8x)
JWH-300[12]Dibenzopyran118 ± 165.3 ± 0.1CB2 (22x)
JWH-301[14]Dibenzopyran295 ± 6448 ± 4CB2 (6.1x)
JWH-302[15]Phenylacetylindole17 ± 289 ± 15CB1 (5.26x)
JWH-303[15]Phenylacetylindole117 ± 10138 ± 12CB1 (1.18x)
JWH-304[15]Phenylacetylindole3363 ± 3322679 ± 688CB2 (1.26x)
JWH-305[15]Phenylacetylindole15 ± 1.829 ± 5CB1 (1.93x)
JWH-306[15]Phenylacetylindole25 ± 182 ± 11CB1 (3.28x)
JWH-307[13]Naphthoylpyrrole7.7 ± 1.83.3 ± 0.2CB2 (2.33x)
JWH-308[13]Naphthoylpyrrole41 ± 133 ± 2CB2 (1.24x)
JWH-309[13]Naphthoylpyrrole41 ± 349 ± 7CB1 (1.20x)
JWH-310[14]Dibenzopyran1059 ± 5136 ± 3CB2 (29x)
JWH-311[15]Phenylacetylindole23 ± 239 ± 3CB1 (1.70x)
JWH-312[15]Phenylacetylindole72 ± 791 ± 20CB1 (1.26x)
JWH-313[15]Phenylacetylindole422 ± 19365 ± 92CB2 (1.16x)
JWH-314[15]Phenylacetylindole39 ± 276 ± 4CB1 (1.95x)
JWH-315[15]Phenylacetylindole430 ± 24182 ± 23CB2 (3.36x)
JWH-316[15]Phenylacetylindole2862 ± 670781 ± 105CB2 (3.66x)
JWH-336[12]Dibenzopyran4589 ± 367153 ± 15CB2 (30x)
JWH-338[14]Dibenzopyran>10000111 ± 16CB2 (>90x)
JWH-339[14]Dibenzopyran>100002317 ± 93CB2 (>4.3x)
JWH-340[14]Dibenzopyran135 ± 630 ± 1CB2 (4.5x)
JWH-341[14]Dibenzopyran100 ± 810 ± 0.1CB2 (10x)
JWH-346[13]Naphthoylpyrrole67 ± 639 ± 2CB2 (1.72x)
JWH-347[13]Naphthoylpyrrole333 ± 17169 ± 17CB2 (1.97x)
JWH-348[13]Naphthoylpyrrole218 ± 1953 ± 1CB2 (4.11x)
JWH-349[14]Dibenzopyran376 ± 138 ± 4CB2 (9.9x)
JWH-350[12]Dibenzopyran395 ± 5012 ± 1CB2 (33x)
JWH-351[14]Dibenzopyran>10000295 ± 3CB2 (>34x)
JWH-352[14]Dibenzopyran>1000047 ± 2CB2 (>213x)
JWH-353[14]Dibenzopyran1493 ± 1031 ± 1CB2 (48x)
JWH-354[14]Dibenzopyran1961 ± 21241 ± 14CB2 (8.1x)
JWH-355[14]Dibenzopyran2162 ± 220108 ± 17CB2 (20x)
JWH-356[14]Dibenzopyran5837 ± 701108 ± 17CB2 (54x)
JWH-357[14]Dibenzopyran647 ± 78185 ± 4CB2 (3.5x)
JWH-358[14]Dibenzopyran1243 ± 26652 ± 3CB2 (24x)
JWH-359Dibenzopyran2918 ± 45013.0 ± 0.2 CB2 (220x)
JWH-360[14]Dibenzopyran2449 ± 606160 ± 8CB2 (15x)
JWH-361[14]Dibenzopyran63 ± 32.7 ± 0.1CB2 (23x)
JWH-362[14]Dibenzopyran127 ± 8 34 ± 5CB2 (3.7x)
JWH-363[13]Naphthoylpyrrole245 ± 571 ± 1CB2 (3.45x)
JWH-364[13]Naphthoylpyrrole34 ± 329 ± 1CB2 (1.17x)
JWH-365[13]Naphthoylpyrrole17 ± 13.4 ± 0.2CB2 (5.0x)
JWH-366[13]Naphthoylpyrrole191 ± 1224 ± 1CB2 (7.96x)
JWH-367[13]Naphthoylpyrrole53 ± 223 ± 1CB2 (2.30x)
JWH-368[13]Naphthoylpyrrole16 ± 19.1 ± 0.7CB2 (1.76x)
JWH-369[13]Naphthoylpyrrole7.9 ± 0.45.2 ± 0.3CB2 (1.52x)
JWH-370[13]Naphthoylpyrrole5.6 ± 0.44.0 ± 0.5CB2 (1.40x)
JWH-371[13]Naphthoylpyrrole42 ± 164 ± 2CB1 (1.52x)
JWH-372[13]Naphthoylpyrrole77 ± 28.2 ± 0.2CB1 (9.39x)
JWH-373[13]Naphthoylpyrrole60 ± 369 ± 2CB1 (1.15x)
JWH-387[17]Naphthoylindole1.2 ± 0.11.1 ± 0.1—
JWH-398[18]Naphthoylindole2.3 ± 0.12.8 ± 0.2CB1 (1.22x)
JWH-416[17]Naphthoylindole73 ± 103.3 ± 0.1CB2 (22x)
JWH-417[17]Naphthoylindole522 ± 5813 ± 0.2CB2 (40x)
JWH-422[17]Naphthoylindole501 ± 4820 ± 0.4CB2 (25x)
JWH-423[17]Naphthoylindole140 ± 106.6 ± 0.2CB2 (21x)
JWH-424[17]Naphthoylindole21 ± 3.45.4 ± 0.2CB2 (3.9x)
JWH-425[17]Naphthoylindole54 ± 1110 ± 0.4CB2 (5.4x)
Close


See also

Notes

  1. [a]
    Ki is the compound's binding affinity for the cannabinoid receptor type 1 (CB1) or cannabinoid receptor type 2 (CB2).

References

Related Articles

Wikiwand AI