JZP-386

JZP-386, also known as deuterated sodium oxybate, deuterated γ-hydroxybutyrate (deu-GHB), or d₄-sodium oxybate, is a deuterated analogue of sodium oxybate (γ-hydroxybutyrate; GHB) which is under development for the treatment of narcolepsy.^[1]^[2]^[3]^[4]^[5] It is taken orally.^[1] In a clinical study, JZP-386 showed greater circulating levels and correspondingly stronger effects than sodium oxybate.^[3]^[4] The drug was originated by Concert Pharmaceuticals (now part of Sun Pharmaceutical Industries) and is under development by Jazz Pharmaceuticals.^[1]^[2] As of March 2023, no recent development has been reported.^[1] JZP-386 reached phase 1 clinical trials by 2014.^[1]^[2] It was said that the enhanced properties of JZP-386 were insufficient to support further clinical development and other avenues are instead being explored.^[3]^[4] There was also interest in JZP-386 for the potential treatment of fibromyalgia.^[4]

Other namesJZP386; C-10323; C10323; d₄-Sodium oxybate; Deuterated sodium oxybate; Deuterated oxybate; Deuterated μ-hydroxybutyrate; Deu-GHB

Routes of
administrationOral^[1]

Drug classGABA_B receptor agonist; GHB receptor agonist; Hypnotic

ATC code

None

Quick facts Clinical data, Other names ...

JZP-386
Clinical data

Other names	JZP386; C-10323; C10323; d₄-Sodium oxybate; Deuterated sodium oxybate; Deuterated oxybate; Deuterated μ-hydroxybutyrate; Deu-GHB
Routes of administration	Oral^[1]
Drug class	GABA_B receptor agonist; GHB receptor agonist; Hypnotic
ATC code	None
Identifiers
CAS Number	1393801-57-4
Chemical and physical data
Formula	C₄H₈NaO₃
Molar mass	127.095 g·mol⁻¹

References

[1]
"JZP 386". AdisInsight. 10 March 2023. Retrieved 15 January 2026.
[2]
"Delving into the Latest Updates on JZP-386 with Synapse". Synapse. 29 November 2025. Retrieved 15 January 2026.
[3]
Chen Y, Du Y (April 2025). "The Application of Deuteration Strategy in Drug Design". ChemMedChem. 20 (7) e202400836. doi:10.1002/cmdc.202400836. PMID 39715028. 3.17. Deuterated Sodium Oxybate (JZP-386) Deuterated sodium oxybate, a kind of dopamine receptor agonist, is a deuterated analog of sodium oxybate developed by CoNCERT and Jazz Pharmaceuticals for the treatment of narcolepsy and fibromyalgia.[85,86] The deuteration process improves the pharmaceutical properties of the drug. According to the results of a phase I trial which applies JZP-386 to thirty healthy volunteers, JZP-386 displays increased serum concentrations and correspondingly higher pharmacodynamic effects compared to sodium oxybate (Xyrem). However, the enhanced characteristics observed in the phase I trial are insufficient to support JZP-386 to enter further clinical trials and therefore the companies are exploring differentiated formulations to enhance the positive effects of deuteration in JZP-386.[86]
[4]
Sullivan SS, Guilleminault C (2015). "Emerging drugs for common conditions of sleepiness: obstructive sleep apnea and narcolepsy". Expert Opinion on Emerging Drugs. 20 (4): 571–582. doi:10.1517/14728214.2015.1115480. PMID 26558298. JZP-386 is a lead compound in a series of deuterium containing analog of sodium oxybate, under development for improved product characteristics (enhanced safety, tolerability and efficacy) for treatment of narcolepsy and fibromyalgia. A phase 1, randomized, single center, single ascending dose, crossover, first-in-humans trial in 28 healthy subjects in Europe, was recently undertaken.106 The Phase 1 study evaluated the safety, pharmacokinetics and pharmacodynamics (PD) of JZP-386 in 30 healthy volunteers. Clinical data from this Phase 1 study demonstrated that JZP-386 provided favorable deuterium-related effects, including higher serum concentrations and correspondingly increased PD effects at clinically relevant time points compared to sodium oxybate oral solution. The safety profile of JZP-386 was similar to that observed with Xyrem. Per press release, the deuterium-related effects observed in the Phase 1 studies did not support advancing into a later-stage clinical trial of JZP-386 at the present time. Accordingly, the companies intend to explore formulation options to enhance the positive effects observed in the studies to achieve an improved product profile for patients with narcolepsy.107
[5]
Pirali T, Serafini M, Cargnin S, Genazzani AA (June 2019). "Applications of Deuterium in Medicinal Chemistry". Journal of Medicinal Chemistry. 62 (11): 5276–5297. Bibcode:2019JMedC..62.5276P. doi:10.1021/acs.jmedchem.8b01808. PMID 30640460. d4-sodium oxibate, 81 (JZP-386) [...]

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