KATNB1

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.^[5][6]

AliasesKATNB1, KAT, LIS6, katanin regulatory subunit B1

External IDsOMIM: 602703; MGI: 1921437; HomoloGene: 4302; GeneCards: KATNB1; OMA:KATNB1 - orthologs

Chr.Chromosome 16 (human)^[1]

End57,757,244 bp^[1]

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KATNB1
Identifiers
Aliases	KATNB1, KAT, LIS6, katanin regulatory subunit B1
External IDs	OMIM: 602703; MGI: 1921437; HomoloGene: 4302; GeneCards: KATNB1; OMA:KATNB1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,735,739 bp[1] End 57,757,244 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 95,807,814 bp[2] End 95,829,777 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus right frontal lobe right uterine tube Brodmann area 23 oocyte prefrontal cortex primary visual cortex Brodmann area 9 endothelial cell Brodmann area 10 Top expressed in seminiferous tubule spermatid spermatocyte yolk sac visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity microtubule-severing ATPase activity microtubule binding dynein complex binding protein binding Cellular component cytoplasm microtubule organizing center growth cone nucleus axon spindle pole membrane centrosome midbody microtubule soma microtubule cytoskeleton plasma membrane cytoskeleton katanin complex cytosol spindle Biological process positive regulation of neuron projection development cell cycle negative regulation of microtubule depolymerization cell division protein targeting microtubule severing positive regulation of cell death positive regulation of microtubule depolymerization microtubule depolymerization mitotic chromosome movement towards spindle pole Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10300 74187 Ensembl ENSG00000140854 ENSMUSG00000031787 UniProt Q9BVA0 Q8BG40 RefSeq (mRNA) NM_005886 NM_028805 RefSeq (protein) NP_005877 NP_083081 Location (UCSC) Chr 16: 57.74 – 57.76 Mb Chr 8: 95.81 – 95.83 Mb PubMed search [3] [4]
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Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.^[6] KATNB1 is associated with microlissencephaly.