KCND1

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as K_v4.1, is a human gene.^[5]

AliasesKCND1, KV4.1, potassium voltage-gated channel subfamily D member 1

External IDsOMIM: 300281; MGI: 96671; HomoloGene: 21035; GeneCards: KCND1; OMA:KCND1 - orthologs

Chr.X chromosome (human)^[1]

End48,971,844 bp^[1]

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KCND1
Identifiers
Aliases	KCND1, KV4.1, potassium voltage-gated channel subfamily D member 1
External IDs	OMIM: 300281; MGI: 96671; HomoloGene: 21035; GeneCards: KCND1; OMA:KCND1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,961,378 bp[1] End 48,971,844 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.1|X 3.53 cM Start 7,688,528 bp[2] End 7,704,519 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right hemisphere of cerebellum left uterine tube stromal cell of endometrium Descending thoracic aorta paraflocculus of cerebellum ascending aorta left coronary artery granulocyte gallbladder Top expressed in lumbar spinal ganglion facial motor nucleus granulocyte gastrula tail of embryo anterior horn of spinal cord genital tubercle superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel activity metal ion binding voltage-gated ion channel activity ion channel activity A-type (transient outward) potassium channel activity voltage-gated potassium channel activity Cellular component integral component of membrane cell projection membrane voltage-gated potassium channel complex plasma membrane soma dendrite cellular component Biological process regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport protein homooligomerization cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3750 16506 Ensembl ENSG00000102057 ENSMUSG00000009731 UniProt Q9NSA2 Q03719 RefSeq (mRNA) NM_004979 NM_008423 RefSeq (protein) NP_004970 NP_032449 Location (UCSC) Chr X: 48.96 – 48.97 Mb Chr X: 7.69 – 7.7 Mb PubMed search [3] [4]
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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.^[5]