KCNK18

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K_2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K_2P18.1 is a potassium channel containing two pore-forming P domains.^[5]

AliasesKCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18

External IDsOMIM: 613655; MGI: 2685627; HomoloGene: 133808; GeneCards: KCNK18; OMA:KCNK18 - orthologs

Chr.Chromosome 10 (human)^[1]

End117,210,299 bp^[1]

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KCNK18
Identifiers
Aliases	KCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18
External IDs	OMIM: 613655; MGI: 2685627; HomoloGene: 133808; GeneCards: KCNK18; OMA:KCNK18 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 117,197,489 bp[1] End 117,210,299 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D3 Start 59,207,646 bp[2] End 59,225,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus prefrontal cortex hypothalamus renal cortex anterior cingulate cortex Top expressed in zygote secondary oocyte primary oocyte embryo placenta More reference expression data BioGPS n/a
Gene ontology Molecular function calcium-activated potassium channel activity outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport cellular response to pH ion transport potassium ion transmembrane transport stabilization of membrane potential potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338567 332396 Ensembl ENSG00000186795 ENSMUSG00000040901 UniProt Q7Z418 Q6VV64 RefSeq (mRNA) NM_181840 NM_207261 RefSeq (protein) NP_862823 NP_997144 Location (UCSC) Chr 10: 117.2 – 117.21 Mb Chr 19: 59.21 – 59.23 Mb PubMed search [3] [4]
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A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.^[6]