KCNK5

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.^[5][6][7]

AliasesKCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5

External IDsOMIM: 603493; MGI: 1336175; HomoloGene: 2773; GeneCards: KCNK5; OMA:KCNK5 - orthologs

Chr.Chromosome 6 (human)^[1]

End39,229,475 bp^[1]

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KCNK5
Identifiers
Aliases	KCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5
External IDs	OMIM: 603493; MGI: 1336175; HomoloGene: 2773; GeneCards: KCNK5; OMA:KCNK5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 39,188,971 bp[1] End 39,229,475 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,190,125 bp[2] End 20,231,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of transverse colon mucosa of ileum oocyte duodenum human kidney kidney tubule secondary oocyte jejunal mucosa skin of leg Top expressed in right kidney proximal tubule intestinal villus human kidney left colon jejunum lumbar spinal ganglion pyloric antrum morula duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated potassium channel activity potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity Cellular component integral component of membrane integral component of plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport excretion ion transport potassium ion transmembrane transport stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8645 16529 Ensembl ENSG00000164626 ENSMUSG00000023243 UniProt O95279 Q9JK62 RefSeq (mRNA) NM_003740 NM_021542 RefSeq (protein) NP_003731 NP_067517 Location (UCSC) Chr 6: 39.19 – 39.23 Mb Chr 14: 20.19 – 20.23 Mb PubMed search [3] [4]
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This gene encodes K_2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.^[7]