KCNK6

Potassium channel subfamily K member 6 is a protein encoded by the KCNK6 gene in humans.^[5][6][7][8]

AliasesKCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6

External IDsOMIM: 603939; MGI: 1891291; HomoloGene: 31266; GeneCards: KCNK6; OMA:KCNK6 - orthologs

Chr.Chromosome 19 (human)^[1]

End38,332,076 bp^[1]

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KCNK6
Identifiers
Aliases	KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	OMIM: 603939; MGI: 1891291; HomoloGene: 31266; GeneCards: KCNK6; OMA:KCNK6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,319,845 bp[1] End 38,332,076 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 16.94 cM Start 28,921,351 bp[2] End 28,931,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua ectocervix monocyte right coronary artery ascending aorta myometrium mucosa of transverse colon vagina smooth muscle tissue parotid gland Top expressed in fossa skin of abdomen right lobe of liver epithelium of stomach Paneth cell parotid gland condyle stroma of bone marrow mesenteric lymph nodes umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inward rectifier potassium channel activity voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane integral component of plasma membrane Biological process regulation of resting membrane potential potassium ion transport regulation of ion transmembrane transport cardiac conduction ion transport negative regulation of systemic arterial blood pressure potassium ion transmembrane transport regulation of systemic arterial blood pressure stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9424 52150 Ensembl ENSG00000099337 ENSMUSG00000046410 UniProt Q9Y257 n/a RefSeq (mRNA) NM_004823 NM_001033525 RefSeq (protein) NP_004814 NP_004814.1 n/a Location (UCSC) Chr 19: 38.32 – 38.33 Mb Chr 7: 28.92 – 28.93 Mb PubMed search [3] [4]
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This gene encodes K_2P6.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid and inhibited by internal acidification and volatile anaesthetics.^[8]