KCNMB3

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.^[5][6]

AliasesKCNMB3, BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3, potassium calcium-activated channel subfamily M regulatory beta subunit 3

External IDsOMIM: 605222; MGI: 3612244; HomoloGene: 18141; GeneCards: KCNMB3; OMA:KCNMB3 - orthologs

Chr.Chromosome 3 (human)^[1]

End179,267,002 bp^[1]

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KCNMB3
Identifiers
Aliases	KCNMB3, BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3, potassium calcium-activated channel subfamily M regulatory beta subunit 3
External IDs	OMIM: 605222; MGI: 3612244; HomoloGene: 18141; GeneCards: KCNMB3; OMA:KCNMB3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.32 Start 179,236,691 bp[1] End 179,267,002 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 32,525,737 bp[2] End 32,546,380 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex testicle gonad body of pancreas spleen placenta sural nerve apex of heart subcutaneous adipose tissue right lobe of liver Top expressed in zygote secondary oocyte primary oocyte embryo adrenal gland hypothalamus blastocyst proximal tubule striatum of neuraxis spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-activated potassium channel activity potassium channel regulator activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane integral component of plasma membrane membrane Biological process detection of calcium ion action potential ion transport neuronal action potential potassium ion transport potassium ion transmembrane transport chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27094 100502876 Ensembl ENSG00000171121 ENSMUSG00000091091 UniProt Q9NPA1 E9Q7U0 RefSeq (mRNA) NM_001163677 NM_014407 NM_171828 NM_171829 NM_171830 NM_001195074 RefSeq (protein) NP_001157149 NP_055222 NP_741979 NP_741980 NP_741981 NP_001182003 Location (UCSC) Chr 3: 179.24 – 179.27 Mb Chr 3: 32.53 – 32.55 Mb PubMed search [3] [4]
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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.^[6]