KCNN4
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[5]
| KCNN4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | KCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602754; MGI: 1277957; HomoloGene: 1696; GeneCards: KCNN4; OMA:KCNN4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[5]
History
The channel activity was first described in 1958 by György Gárdos in human erythrocytes.[6] The channel is also named Gardos channel because of its discoverer.
