KIF18A

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.[5][6] It is part of the kinesin family of motor proteins.

PDBOrtholog search: PDBe RCSB
AliasesKIF18A, MS-PPP1R99, kinesin family member 18A
Quick facts Available structures, PDB ...
KIF18A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIF18A, MS-PPP1R99, kinesin family member 18A
External IDsOMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA:KIF18A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031217

NM_139303

RefSeq (protein)

NP_112494

NP_647464

Location (UCSC)Chr 11: 28.02 – 28.11 MbChr 2: 109.11 – 109.17 Mb
PubMed search[3][4]
Wikidata
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Function

KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.[7]

KIF18a(-/-) knockout in mice results in complete sterility in males, but not females, due to abnormal development of the seminiferous tubules.[8] The mice were otherwise normal, suggesting KIF18a is not essential for cell divisions in non-germ cells.

Therapeutic Target

KIF18A has been considered as a cancer target because it is overexpressed in many cancer types and mouse studies suggest it is dispensable in somatic cells.[9] As such, small molecule inhibitors of KIF18A have been developed to block its activity. [9]

References

Further reading

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