KIF18A
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.[5][6] It is part of the kinesin family of motor proteins.
External IDsOMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA:KIF18A - orthologs
Function
KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.[7]
KIF18a(-/-) knockout in mice results in complete sterility in males, but not females, due to abnormal development of the seminiferous tubules.[8] The mice were otherwise normal, suggesting KIF18a is not essential for cell divisions in non-germ cells.