KLF12

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.^[5][6]

AliasesKLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12

External IDsOMIM: 607531; MGI: 1333796; HomoloGene: 21417; GeneCards: KLF12; OMA:KLF12 - orthologs

Chr.Chromosome 13 (human)^[1]

End74,133,929 bp^[1]

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KLF12
Identifiers
Aliases	KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs	OMIM: 607531; MGI: 1333796; HomoloGene: 21417; GeneCards: KLF12; OMA:KLF12 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q22.1 Start 73,686,089 bp[1] End 74,133,929 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E2.2-E2.3|14 50.9 cM Start 99,870,632 bp[2] End 100,284,679 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis superficial temporal artery retinal pigment epithelium caput epididymis Brodmann area 23 biceps brachii Skeletal muscle tissue of biceps brachii tendon of biceps brachii epithelium of nasopharynx synovial joint Top expressed in Rostral migratory stream human fetus tail of embryo genital tubercle retinal pigment epithelium dorsal tegmental nucleus habenula lateral septal nucleus lateral geniculate nucleus medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding transcription corepressor activity metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11278 16597 Ensembl ENSG00000118922 ENSMUSG00000072294 UniProt Q9Y4X4 O35738 RefSeq (mRNA) NM_007249 NM_016285 NM_010636 RefSeq (protein) NP_009180 NP_034766 Location (UCSC) Chr 13: 73.69 – 74.13 Mb Chr 14: 99.87 – 100.28 Mb PubMed search [3] [4]
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Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.^[6]