KLF13
Protein found in humans
From Wikipedia, the free encyclopedia
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[5][6][7]
| KLF13 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | KLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605328; MGI: 1354948; HomoloGene: 32288; GeneCards: KLF13; OMA:KLF13 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[8] Ghrelin levels also positively correlated with methylation levels of cg07814318.[8] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[8]
Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[5][9]
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[7] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[7][10][11][12][13][14][15]
Interactions
KLF13 has been shown to interact with CREB-binding protein,[16] Heat shock protein 47[16] and PCAF.[16]