Kallikrein-5

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene.^{[5][6][7][8][9][10]} This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.^[10]

PDBHuman UniProt search: PDBe RCSB

AliasesKLK5, KLK-L2, KLKL2, SCTE, kallikrein related peptidase 5

External IDsOMIM: 605643; MGI: 1915918; HomoloGene: 75000; GeneCards: KLK5; OMA:KLK5 - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts KLK5, Available structures ...

KLK5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2PSX, 2PSY
Identifiers
Aliases	KLK5, KLK-L2, KLKL2, SCTE, kallikrein related peptidase 5
External IDs	OMIM: 605643; MGI: 1915918; HomoloGene: 75000; GeneCards: KLK5; OMA:KLK5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 50,943,303 bp[1] End 50,953,093 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.3 cM Start 43,491,395 bp[2] End 43,500,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg skin of abdomen skin of thigh human penis skin of hip vulva gums gingival epithelium sperm Top expressed in lip skin of external ear skin of abdomen skin of back esophagus umbilical cord embryo epidermis blastocyst condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity peptidase activity serine-type peptidase activity endopeptidase activity serine-type endopeptidase activity Cellular component epidermal lamellar body extracellular region extracellular space cytosol secretory granule Biological process positive regulation of antibacterial peptide production positive regulation of G protein-coupled receptor signaling pathway proteolysis epidermis development cornification extracellular matrix disassembly amelogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25818 68668 Ensembl ENSG00000167754 ENSMUSG00000074155 UniProt Q9Y337 n/a RefSeq (mRNA) NM_001077491 NM_001077492 NM_012427 NM_026806 RefSeq (protein) NP_001070959 NP_001070960 NP_036559 n/a Location (UCSC) Chr 19: 50.94 – 50.95 Mb Chr 7: 43.49 – 43.5 Mb PubMed search [3] [4]
Wikidata
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KLK5 has been suggested to regulate cell shedding (desquamation) in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. It is proposed that KLK5 regulates this process since it is able to self-activate in addition to activating KLK7 and KLK14.^[11]