Importin subunit alpha-6

Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene.^[3]

PDBHuman UniProt search: PDBe RCSB

AliasesKPNA5, IPOA6, SRP6, karyopherin subunit alpha 5

External IDsOMIM: 604545; HomoloGene: 128489; GeneCards: KPNA5; OMA:KPNA5 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts KPNA5, Available structures ...

KPNA5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4U2X
Identifiers
Aliases	KPNA5, IPOA6, SRP6, karyopherin subunit alpha 5
External IDs	OMIM: 604545; HomoloGene: 128489; GeneCards: KPNA5; OMA:KPNA5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.1 Start 116,681,187 bp[1] End 116,741,866 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon Brodmann area 23 middle temporal gyrus pons tibia bronchial epithelial cell endothelial cell retinal pigment epithelium buccal mucosa cell germinal epithelium n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclear localization sequence binding protein binding nuclear import signal receptor activity Cellular component nuclear pore nucleus nucleoplasm cytoplasm cytosol Biological process protein transport modulation by virus of host cellular process NLS-bearing protein import into nucleus protein import into nucleus viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3841 n/a Ensembl ENSG00000196911 n/a UniProt O15131 Q5TD90 n/a RefSeq (mRNA) NM_002269 n/a RefSeq (protein) NP_002260 NP_001353233 NP_001353234 NP_001353235 NP_001353236 NP_001353237 NP_001353238 NP_001353239 n/a Location (UCSC) Chr 6: 116.68 – 116.74 Mb n/a PubMed search [2] n/a
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The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs).

KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus^[4]