Keratin 15

KRT15
Identifiers
Aliases	KRT15, CK15, K15, K1CO, keratin 15
External IDs	OMIM: 148030; MGI: 96689; HomoloGene: 1712; GeneCards: KRT15; OMA:KRT15 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,522,529 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,026,754 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; skin of thigh; ; skin of arm; ; skin of abdomen; ; epithelium of nasopharynx; ; gums; ; gingival epithelium; ; cervix epithelium; ; vulva; ; skin of hip;
	Top expressed in
	conjunctival fornix; ; skin of abdomen; ; lip; ; esophagus; ; transitional epithelium of urinary bladder; ; skin of external ear; ; cornea; ; skin of back; ; umbilical cord; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	scaffold protein binding; structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	extracellular exosome; intermediate filament; nucleus; cytosol;
Biological process	epidermis development; cytoskeleton organization; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3866
	16665
	ENSG00000171346
	ENSMUSG00000054146
	P19012
	Q61414
	NM_002275
	NM_008469
	NP_002266
	NP_032495
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 15 is a protein that in humans is encoded by the KRT15 gene.^[5]^[6] It has also been referred to as cytokeratin 15, K1CO and KRTB.

AliasesKRT15, CK15, K15, K1CO, keratin 15

External IDsOMIM: 148030; MGI: 96689; HomoloGene: 1712; GeneCards: KRT15; OMA:KRT15 - orthologs

Chr.Chromosome 17 (human)^[1]

End41,522,529 bp^[1]

Quick facts KRT15, Identifiers ...

Close

Keratin 15 is a type I cytokeratin. It is well-expressed in the basal layer of complex epithelia. However, acral keratinocytes express little to no keratin 15.^[7]

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[6]

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Keratin 15

References

Further reading

Related Articles

Related Articles

"New consensus nomenclature for mammalian keratins"

"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes"

"Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription"

"Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene"

"Molecular characterization and expression of the stratification-related cytokeratins 4 and 15"

"The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins"

"Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease"