Keratin 16

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.^[5][6][7]

AliasesKRT16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1, keratin 16

External IDsOMIM: 148067; MGI: 96690; HomoloGene: 21145; GeneCards: KRT16; OMA:KRT16 - orthologs

Chr.Chromosome 17 (human)^[1]

End41,615,899 bp^[1]

Quick facts KRT16, Identifiers ...

KRT16
Identifiers
Aliases	KRT16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1, keratin 16
External IDs	OMIM: 148067; MGI: 96690; HomoloGene: 21145; GeneCards: KRT16; OMA:KRT16 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,609,778 bp[1] End 41,615,899 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 100,136,917 bp[2] End 100,139,728 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium hair follicle buccal mucosa cell amniotic fluid skin of abdomen skin of leg periodontal fiber cervix epithelium body of tongue epithelium of esophagus Top expressed in lip middle ear epidermis Eustachian tube zone of skin olfactory system corneal epithelium urethra vagina mandibular molars More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of cytoskeleton protein binding structural molecule activity Cellular component extracellular exosome cytoskeleton intermediate filament nucleus cytosol Biological process morphogenesis of an epithelium hair cycle keratinocyte migration ageing cell population proliferation inflammatory response negative regulation of cell migration innate immune response cytoskeleton organization keratinocyte differentiation epidermis development intermediate filament cytoskeleton organization establishment of skin barrier keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3868 16666 Ensembl ENSG00000186832 ENSMUSG00000053797 UniProt P08779 Q9Z2K1 RefSeq (mRNA) NM_005557 NM_008470 NM_001313958 RefSeq (protein) NP_005548 NP_001300887 NP_032496 Location (UCSC) Chr 17: 41.61 – 41.62 Mb Chr 11: 100.14 – 100.14 Mb PubMed search [3] [4]
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Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.^[8]