KRT33A

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.^[5][6][7]

AliasesKRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A

External IDsOMIM: 602761; MGI: 1919138; HomoloGene: 135742; GeneCards: KRT33A; OMA:KRT33A - orthologs

Chr.Chromosome 17 (human)^[1]

End41,350,828 bp^[1]

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KRT33A
Identifiers
Aliases	KRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A
External IDs	OMIM: 602761; MGI: 1919138; HomoloGene: 135742; GeneCards: KRT33A; OMA:KRT33A - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,346,092 bp[1] End 41,350,828 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 99,902,021 bp[2] End 99,907,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle mucosa of esophagus left testis right testis skin of abdomen vagina skin of leg minor salivary glands right lung ectocervix Top expressed in lip hair follicle skin of back dermis skin of external ear skin of abdomen sexually immature organism medial head of gastrocnemius muscle conjunctival fornix diencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament extracellular space cytosol Biological process keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3883 71888 Ensembl ENSG00000261986 ENSG00000006059 ENSMUSG00000035592 UniProt O76009 Q8K0Y2 RefSeq (mRNA) NM_004138 NM_027983 RefSeq (protein) NP_004129 NP_082259 Location (UCSC) Chr 17: 41.35 – 41.35 Mb Chr 11: 99.9 – 99.91 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A (this gene) and KRT33B.^[7]