KRT85

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.^[5][6][7]

AliasesKRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85

External IDsOMIM: 602767; MGI: 1859268; HomoloGene: 37603; GeneCards: KRT85; OMA:KRT85 - orthologs

Chr.Chromosome 12 (human)^[1]

End52,367,481 bp^[1]

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KRT85
Identifiers
Aliases	KRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85
External IDs	OMIM: 602767; MGI: 1859268; HomoloGene: 37603; GeneCards: KRT85; OMA:KRT85 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,360,006 bp[1] End 52,367,481 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 Start 101,413,801 bp[2] End 101,422,054 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm sperm testicle skin of hip hair follicle skin of thigh nipple gonad right lung skin of abdomen Top expressed in lip zone of skin testicle spermatid limb islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament keratin filament extracellular space cytosol Biological process epidermis development keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3891 53622 Ensembl ENSG00000135443 ENSMUSG00000116336 UniProt P78386 Q9Z2T6 RefSeq (mRNA) NM_002283 NM_001300810 NM_016879 RefSeq (protein) NP_001287739 NP_002274 NP_058575 Location (UCSC) Chr 12: 52.36 – 52.37 Mb Chr 15: 101.41 – 101.42 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.^[7]