L-694247

L-694247 is a selective serotonin 5-HT_1B and 5-HT_1D full agonist, with similar affinities and activational potencies at these two receptors, about 20- to 25-fold greater affinity for the serotonin 5-HT_1D receptor over the serotonin 5-HT_1A receptor, and negligible affinity for the serotonin 5-HT_1E and 5-HT_1F receptors.^[1][2]

Quick facts Names, Identifiers ...

L-694247

Names
Preferred IUPAC name N-[4-({5-[3-(2-Aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl}methyl)phenyl]methanesulfonamide
Identifiers
CAS Number	137403-12-4 N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:92341
ChEMBL	ChEMBL39317
ChemSpider	116658
PubChem CID	132059
CompTox Dashboard (EPA)	DTXSID20160175
InChI InChI=1S/C20H21N5O3S/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18/h2-7,11-12,22,25H,8-10,21H2,1H3 Key: HKXMQLISPYELRD-UHFFFAOYSA-N
SMILES CS(=O)(=O)Nc1ccc(cc1)Cc2nc(on2)c3ccc4c(c3)c(c[nH]4)CCN
Properties
Chemical formula	C20H21N5O3S
Molar mass	411.48 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a serotonin 5-HT_1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.^[3]

L-694247 is a 5-substituted tryptamine derivative.^[4]