LARS2

Probable leucyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the LARS2 gene.^[5][6]

AliasesLARS2, LEURS, PRLTS4, mtLeuRS, leucyl-tRNA synthetase 2, mitochondrial, HLASA

External IDsOMIM: 604544; MGI: 2142973; HomoloGene: 6526; GeneCards: LARS2; OMA:LARS2 - orthologs

Chr.Chromosome 3 (human)^[1]

End45,554,726 bp^[1]

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LARS2
Identifiers
Aliases	LARS2, LEURS, PRLTS4, mtLeuRS, leucyl-tRNA synthetase 2, mitochondrial, HLASA
External IDs	OMIM: 604544; MGI: 2142973; HomoloGene: 6526; GeneCards: LARS2; OMA:LARS2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 45,388,561 bp[1] End 45,554,726 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 73.92 cM Start 123,195,992 bp[2] End 123,291,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone oocyte secondary oocyte Brodmann area 23 mucosa of transverse colon kidney tubule caudate nucleus retinal pigment epithelium prefrontal cortex ganglionic eminence Top expressed in zygote yolk sac lip superior frontal gyrus spermatocyte muscle of thigh tail of embryo ventricular zone genital tubercle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity ATP binding aminoacyl-tRNA editing activity leucine-tRNA ligase activity Cellular component mitochondrial matrix mitochondrion Biological process tRNA aminoacylation for protein translation protein biosynthesis leucyl-tRNA aminoacylation mitochondrial translation aminoacyl-tRNA metabolism involved in translational fidelity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23395 102436 Ensembl ENSG00000011376 ENSMUSG00000035202 UniProt Q15031 Q8VDC0 RefSeq (mRNA) NM_015340 NM_001368263 NM_153168 NM_001348167 NM_001348168 RefSeq (protein) NP_056155 NP_001355192 NP_694808 NP_001335096 NP_001335097 Location (UCSC) Chr 3: 45.39 – 45.55 Mb Chr 9: 123.2 – 123.29 Mb PubMed search [3] [4]
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This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.^[6]