LBX1

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.^[5][6]

AliasesLBX1, HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1, CCHS3

External IDsOMIM: 604255; MGI: 104867; HomoloGene: 4784; GeneCards: LBX1; OMA:LBX1 - orthologs

Chr.Chromosome 10 (human)^[1]

End101,229,463 bp^[1]

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LBX1
Identifiers
Aliases	LBX1, HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1, CCHS3
External IDs	OMIM: 604255; MGI: 104867; HomoloGene: 4784; GeneCards: LBX1; OMA:LBX1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 101,226,994 bp[1] End 101,229,463 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 45,221,123 bp[2] End 45,224,251 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh testicle skeletal muscle tissue right hemisphere of cerebellum C1 segment right lung frontal lobe Cortex of frontal lobe dorsolateral prefrontal cortex Top expressed in triceps brachii muscle muscle of thigh lumbar subsegment of spinal cord ankle vastus lateralis muscle gastrocnemius muscle tibialis anterior muscle skeletal muscle tissue zygote soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex Biological process multicellular organism development heart looping anatomical structure morphogenesis cell differentiation muscle organ development neuron fate commitment spinal cord motor neuron differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation neuron fate determination transcription, DNA-templated nervous system development negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10660 16814 Ensembl ENSG00000138136 ENSMUSG00000025216 UniProt P52954 P52955 RefSeq (mRNA) NM_006562 NM_010691 RefSeq (protein) NP_006553 NP_034821 Location (UCSC) Chr 10: 101.23 – 101.23 Mb Chr 19: 45.22 – 45.22 Mb PubMed search [3] [4]
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This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes.

In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.^[6]