LHX6

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.^[5][6]

AliasesLHX6, LHX6.1, LIM homeobox 6, hLHX6

External IDsOMIM: 608215; MGI: 1306803; HomoloGene: 7401; GeneCards: LHX6; OMA:LHX6 - orthologs

Chr.Chromosome 9 (human)^[1]

End122,229,626 bp^[1]

Quick facts Identifiers, Aliases ...

LHX6
Identifiers
Aliases	LHX6, LHX6.1, LIM homeobox 6, hLHX6
External IDs	OMIM: 608215; MGI: 1306803; HomoloGene: 7401; GeneCards: LHX6; OMA:LHX6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2 Start 122,202,577 bp[1] End 122,229,626 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 35,971,965 bp[2] End 35,995,420 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad subcutaneous adipose tissue prefrontal cortex anterior cingulate cortex endothelial cell orbitofrontal cortex Brodmann area 46 ganglionic eminence visceral pleura parietal pleura Top expressed in medial ganglionic eminence maxillary prominence molar entorhinal cortex barrel cortex CA3 field perirhinal cortex mandibular prominence globus pallidus female urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process multicellular organism development cerebral cortex GABAergic interneuron migration cell differentiation regulation of transcription, DNA-templated cerebral cortex radially oriented cell migration cerebral cortex tangential migration cell maturation transcription, DNA-templated nervous system development regulation of transcription by RNA polymerase II forebrain neuron development neuron differentiation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26468 16874 Ensembl ENSG00000106852 ENSMUSG00000026890 UniProt Q9UPM6 Q9R1R0 RefSeq (mRNA) NM_001242333 NM_001242334 NM_001242335 NM_014368 NM_199160 NM_001348190 NM_001083125 NM_001083126 NM_001083127 NM_008500 NM_001355125 RefSeq (protein) NP_001229262 NP_001229263 NP_001229264 NP_055183 NP_954629 NP_001335119 NP_001229263.1 NP_001076594 NP_001076595 NP_001076596 NP_032526 NP_001342054 Location (UCSC) Chr 9: 122.2 – 122.23 Mb Chr 2: 35.97 – 36 Mb PubMed search [3] [4]
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This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.^[6]